1042421-51-1

Basic information

• Product Name: C₁₇H₁₄F₆N₂O₆S₂
• CAS NO: 1042421-51-1
• Molecular Weight: 520.43
• Mol File: 1042421-51-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₄F₆N₂O₆S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₄F₆N₂O₆S₂(1042421-51-1)
• EPA Substance Registry System: C₁₇H₁₄F₆N₂O₆S₂(1042421-51-1)

Safety Data

• Hazardous Substances Data: 1042421-51-1(Hazardous Substances Data)

Upstream product

• 776-04-5 2-trifluoromethylbenzenesulfonyl chloride 
• 18635-45-5 D,L-α,β-diaminopropionic acid monohydrobromide 

Downstream Products

• 1042421-73-7 C₂₄H₂₁F₆N₃O₆S₂ 

Relevant articles and documents

Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors

A series of bis-(arylsulfonamide) hydroxamate inhibitors were synthesized. These compounds exhibit good potency against MMP-7 and MMP-9 depending on the nature, steric bulk, and substitution pattern of the substituents in the benzene ring. In general, the preliminary structure-activity relationships (SAR) suggest that among the DAPA hydroxamates (i) electron-rich benzene rings of the sulfonamides may produce better inhibitors than electron-poor analogs. However, potential H-bond acceptors can reverse the trend depending on the isozyme; (ii) isozyme selectivity between MMP-7 and -9 can be conferred through steric bulk and substitution pattern of the substituents in the benzene ring, and (iii) the MMP-10 inhibition pattern of the compounds paralleled that for MMP-9.