10426-00-3Relevant academic research and scientific papers
Bifunctional copper-based photocatalyst for reductive pinacol-type couplings
Caron, Antoine,Morin, émilie,Collins, Shawn K.
, p. 9458 - 9464 (2019)
A bifunctional copper-based photocatalyst has been prepared that employs a pyrazole-pyridine ligand incorporating a sulfonamide moiety that functions as an intramolecular hydrogen-bond donor for a photochemical PCET process. In typical reductive PCET processes, the photocatalyst and H-bond donor must have an appropriate redox potential and pKa, respectively, to promote the PCET. When working in concert in a bifunctional catalyst such as Cu(pypzs)(BINAP)BF4, the pKa of the H-bond donor can have an acidity that is orders of magnitude less and still efficiently promote the PCET process. A reductive pinacol-type coupling can be performed using a base-metal derived photocatalyst to afford valuable diols (24 examples, 46-99% yield), from readily available aldehydes and ketones.
Direct measurement of ultrafast carbon-carbon cleavage rates via the subpicosecond charge-transfer activation of pinacols
Bockman,Hubig,Kochi
, p. 6542 - 6547 (2007/10/03)
Highly transient (benzpinacol) cation radicals (D2+.) and their ultrafast mesolytic fragmentations to the diarylhydroxymethyl radical (D.) and cation (D+) are directly observed on the early picosecond time scale upon the charge-transfer photoactivation of the intermolecular donor-acceptor complexes of pinacol donors with methyl viologen. Ultrashort lifetimes of the cation radicals with τ ~ 10 ps obtain (for the first time) from quantitative kinetics analysis of the time-resolved spectroscopic results. These rapid C-C bond scissions successfully compete with back-electron transfer, which normally predominates on this time scale, and lead to exceptionally high efficiencies for the oxidative fragmentation of pinacols.
Studies on the Occurrence of Hydrogen Transfer, 73. - The Reduction of Prochiral Alkyl (Aryl) Ketones with Alkali Metal Amalgams Forming Carbinols and Pinakols
Horner, Leopold,Dickerhof, Karlheinz
, p. 1240 - 1258 (2007/10/02)
The factors are determined which influence the stereochemistry and the ratio (C/P) in the reduction of acetophenone with lithium, sodium, and potassium amalgam (Li/Hg, Na/Hg, K/Hg) leading to carbinol (C) and pinacol(P).The C/P ratio is influenced a) by proton donators, b) by quaternaryammonium salts, c) by bis-tertiary amines.In the presence of optically active quaternary ammonium salts and optically active bis-tertiary amines a low optical induction is observed both in pinacol and carbinol.An anomal dimerization product 20 is formed in the reduction of pivalophenone with Li/Hg.
