104261-79-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)2,3-DIHYDRO-INDOLE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER is used as a building block for the synthesis of various biologically active molecules and pharmaceuticals. Its unique structure and properties allow it to be a key component in the development of new drugs and therapeutic agents.
The exact biological and pharmacological properties and applications of (S)2,3-DIHYDRO-INDOLE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER are areas of ongoing research and exploration, indicating its potential for future advancements in medicine and healthcare.

Upstream product

• 763047-58-1 (R)-indoline-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 135829-03-7 methyl (+/-)-1-benzyloxycarbonyl-indoline-2-carboxylate 
• 79815-20-6 (S)-indoline-2-carboxylic acid 

Downstream Products

• 220648-65-7 (S)-1-pyrrolidine 
• 220648-66-8 (S)-4-morpholine 
• 220648-67-9 (S)-4-methyl-1-piperazine 
• 220648-68-0 (S)-4-benzyl-1-piperazine 
• 185213-04-1 N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid propylamide 
• 185213-12-1 N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid ethylamide 
• 185213-08-5 N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid methylamide 
• 185213-00-7 N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid n-butylamide 
• 104261-80-5 1-benzyloxycarbonyl-2S-indolinecarboxylic acid anilide 
• 116586-56-2 t-butyl 1-benzyloxycarbonyl-indoline-2(S)-carboxylate 
• 1029798-59-1 (S)-2-(4-phenyl-thiazol-2-ylcarbamoyl)-2,3-dihydro-indole-l-carboxylic acid benzyl ester 
• 1031747-42-8 (S)-2-(2-amino-5-bromophenylcarbamoyl)-2,3-dihydroindole-1-carboxylic acid benzyl ester 
• 1031747-41-7 (S)-2-(2-amino-4-bromophenylcarbamoyl)-2,3-dihydroindole-1-carboxylic acid benzyl ester 
• 1056039-69-0 (S)-benzyl 2-(methoxy(methyl)carbamoyl)indoline-1-carboxylate 

Relevant academic research and scientific papers

On the origins of enantioselectivity in oxazaborolidine mediated carbonyl reductions

A series of tricyclic oxazaborolidine catalysts have been prepared from readily available (S)-indoline-2-carboxylic acid. In each case, an arene chromium(0) carbonyl group was introduced on one face of the catalyst. Results obtained in the borane mediated

Cis-fused ring-containing β-lactam the synthetic method of the compound of

The invention discloses a synthetic method of a beta-lactam compound with a cis condensed ring. Substituted or un-substituted pyrrole-2-formic acid, or substituted or un-substituted pyridine-2-formic acid or substituted or un-substituted indole-2-formic acid is used as a starting material, Pd(II) is adopted as a catalyst, and AgOAc or Ag2CO3 is used as an oxidant; a sp3C-H bond at a beta site of an amide substrate 2 (for example Scheme4) is activated through palladium catalysis; a key step of forming a C-N bond in a molecule to successfully construct a beta-lactam framework with the cis condensed ring is generated. According to the synthetic method disclosed by the invention, materials are simple and easily available, the price is cheap, the experiment operation is simple, the route is short and the yield is high; the synthetic method has very high atom economy, a little waste, environment friendliness, a wide scope of application of the substrate and good universality, and can be used for efficiently obtaining the beta-lactam compound with optical activity kept in a chiral manner.

ANTIMICROBIAL INDOLINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS

The present invention provides indoline heterocyclic compounds of the following formula I: or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods f

ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS

The present invention provides heterocyclic compounds of the following formula (I) : or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Tetrazolic acid functionalized dihydroindol: Rational design of a highly selective cyclopropanation organocatalyst

(Chemical Equation Presented) Herein we wish to report our development of an improved catalyst (S)-(-)-indoline-2-yl-1H-tetrazole (1) for the enantioselective organocatalyzed cyclopropanation of α,β-unsaturated aldehydes with sulfur ylides. The new organo

Both enantiomers of N-Boc-indoline-2-carboxylic esters

An immobilized form of Candida antarctica lipase (Chirazyme L-2) catalyzed enantioselective hydrolysis (E > 1000) of N-Boc-indoline-2-carboxylic acid methyl ester. The reaction proceeded efficiently at 60 °C, a temperature over the melting point of substrate, in the conversion of 49.9% to provide the hydrolyzed product, (S)-carboxylic acid with >99.9% ee and the unreacted (R)-ester with 99.6% ee. A newly developed expeditious route to the racemic substrate (a total of six steps, 60% yield), starting from aniline and ethyl α-methylacetoacetate, established the scalable chemoenzymatic synthesis of the desired compounds in both enantiomerically pure forms.

Tripeptidylpeptidase inhibitors

A compound of formula wherein the substituents are defined as in the specification and salts or hydrates thereof is disclosed as well as a method of treating disorders associated with the inactivation or excessive degradation of cholecystokinin.

Enantioselective addition of dialkylzinc to aldehydes catalyzed by (S)- 2-(N,N-disubstituted aminomethyl)indoline

Chirai di- or triamines, (S)-2-(N,N-disubstituted aminomethyl)indoline 1a-d, derived from (S)-indoline-2-carboxylic acid were efficient chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The best results were obtained by empl

Process for the preparation of an indoline carboxylic acid

The invention relates to a novel process for the preparation of the optically pure 2S- or 2R-indolinecarboxylic acid of the formula STR1 and salts thereof. The process comprises forming the heterocyclic 5-membered ring in formula I from an open chain prec