104265-90-9

Upstream product

• 93603-11-3 1-methyl hydrogen 1,2-cis-1,2-cyclohex-4-ene dicarboxylate 
• 31139-02-3 (1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid 
• 19914-76-2 (1S-cis)-6-Chlorcarbonyl-3-cyclohexen-1-carbonsaeure-methylester 
• 78647-11-7 methyl-6-formyl-3-cyclohexenecarboxylic acid 
• 5837-72-9 methyl (E)-4-oxo-2-butenoate 

Downstream Products

• 129482-72-0 (1R,3S,4R,5S)-5-[1,3]Dithian-2-ylidenemethyl-4-hydroxymethyl-cyclohexane-1,3-diol 
• 129482-80-0 methyl (Z,3S,5R)-[3,5-bis(tert-butyldimethylsilyl)oxy-2-methylenecyclohexylidene]acetate 
• 129482-78-6 [(2R,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-cyclohex-(Z)-ylidene]-acetic acid methyl ester 
• 129482-76-4 (4R,4aS,6R,8S,8aR)-6,8-Bis-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-octahydro-isochromen-3-one 
• 121961-83-9 Sodium; (1S,6R)-6-hydroxymethyl-cyclohex-3-enecarboxylate 
• 129482-79-7 [(2S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-(2-nitro-phenylselanylmethyl)-cyclohex-(Z)-ylidene]-acetic acid methyl ester 
• 2744-06-1 trans-6-cyanomethyl-3-cyclohexenecarboxylic acid 
• 89560-15-6 ((1R,4S,6R)-4-Hydroxy-6-hydroxymethyl-cyclohex-2-enyl)-acetonitrile 
• 78647-12-8 methyl trans-6-cyanomethyl-3-cyclohexenecarboxylate 
• 80365-88-4 (1S*,4R*,6S*)-4-hydroxy-6-hydroxymethyl-2-cyclohexene-acetonitrile bis (tetrahydropyranyl) ether 
• 78647-17-3 methyl (1R*,2S*,4R*,6S*)-(Z)-2-acetylthio-4-hydroxy-6-hydroxymethylcyclohexanehept-5-enoate 
• 78647-14-0 [(1R,4S,6R)-4-(Tetrahydro-pyran-2-yloxy)-6-(tetrahydro-pyran-2-yloxymethyl)-cyclohex-2-enyl]-acetic acid 
• 78647-18-4 methyl (1R*,2S*,4R*,6S*)-(Z)-2-acetylthio-4-(tetrahydro-2-pyranyloxy)-6-hydroxymethylcyclohexanehept-5-enoate 
• 80365-92-0 (Z)-7-[(1S,4S,6R)-2-Oxo-4-(tetrahydro-pyran-2-yloxy)-6-(tetrahydro-pyran-2-yloxymethyl)-cyclohexyl]-hept-5-enoic acid methyl ester 

Relevant academic research and scientific papers

Concise synthesis of the tricyclic core of platencin

(Chemical Equation Presented) A radical change: Implementation of a radical-mediated rearrangement of the bicyclo[3.2.1]octyl moiety to the bicyclo-[2.2.2]octane structure has enabled a concise synthesis of the tricyclic core of platencin, a newly discove

ADENYLYL CYCLASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF

The present invention relates to novel adenine based inhibitors of adenylyl cyclase of the formula: wherein X, L, R1, R2, R5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.

An enantioselective synthesis of the A-ring synthon for vitamin D3 metabolites by chemicoenzymatic approach

The A-ring synthon for vitamin D3 metabolites having 1α-hydroxyl group is synthesized starting from a chiral monoester 6 enzymatically generated.

SYNTHESIS OF THROMBOXANE A2 ANALOGS-2. (+/-)-THIATHROMBOXANE A2

The total synthesis of (+/-)-11a-methano-9,11-thiathromboxane A2(1), the sulfur analog of thromboxane A2 is described.

A Study of Stereoselective Hydrolysis of Symmetrical Diesters with Pig Liver Esterase

Pig liver esterase (PLE) catalyzed hydrolysis of dimethyl esters of symmetrical dicarboxylic acids, including meso-diacids, cis-1,2-cycloalkanedicarboxylic acids, and diacids with a prochiral center, was studied with 14 substrates.The products of these stereoselective hydrolyses are chiral monoesters of dicarboxylic acids, with an enantiomeric excess (e.e.) from 10percent to 100percent.Some of these optically active monoesters are valuable synthons in natural products synthesis.An additivity pattern of α- and β-substituents with the glutaric esters on the stereoselectivity of enzymatic hydrolysis was observed.Analysis of the experimental results leads to a model of enzyme stereoselectivity of diester hydrolysis in which the substitution pattern at α- and β-C-atoms is found to determine the absolute configuration of the resulting monoester.