104267-39-2

Upstream product

• 5724-81-2 1-pyrroline 
• 104267-38-1 tert-Butyl-[(E)-1-ethoxy-2-(4-methoxy-phenyl)-3-methyl-buta-1,3-dienyloxy]-dimethyl-silane 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 104267-37-0 2-(4-Methoxy-phenyl)-3-methyl-but-2-enoic acid ethyl ester 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 220312-31-2 2-[3-(phenylthio)prop-2-enyl]-N-[α-(p-methoxyphenyl)-α-(phenylthio)acetyl]pyrrolidine 
• 220312-32-3 6-(4-methoxy-phenyl)-7-phenylsulfanylmethyl-hexahydro-indolizin-5-one 
• 220312-30-1 2-(4-Methoxy-phenyl)-1-[2-((E)-3-phenylsulfanyl-allyl)-pyrrolidin-1-yl]-ethanone 

Downstream Products

• 26294-41-7 4-[7-methyl-1,2,3,5,8,8a-hexahydroindolizin-6-yl]phenol 
• 29079-30-9 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine 

Relevant academic research and scientific papers

Superacid-promoted synthesis of indolizidine derivatives

A series of amido-acetals were reacted with the Br?nsted superacid, CF3SO3H, to provides indolizidine derives by a cyclization cascade. A mechanism is proposed involving formation of a vinylogous enol which undergoes a 6π-electrocycl

A synthesis of (±)-ipalbidine using sulfur-controlled 6-exo selective radical cyclization of α-phenylthio amide

A synthesis of (±)-ipalbidine (1) has been achieved using Bu3SnH- mediated 6-exo selective radical cyclization of 2-[3-(phenylthio)prop-2- enyl]-N-[α(p-methoxyphenyl)-α-(phenylthio)acetyl]pyrrolidine (15) as a key step.

A Concise Total Synthesis of (+/-)-Ipalbidine by Application of the Aldimine-Diene Cyclocondensation Reaction

The scope of the diene-imine cyclocondensation reaction has been extended to the unstable Δ1-pyrroline.Cyclocondensation of this compound with the silylketene acetal derived from ethyl 2-p-anisyl-3-methylcrotonate provides the basis for a rapid