10427-74-4

Upstream product

• 183878-41-3 p-nitrophenyl 3,6-dideoxy-3-chloro-4-O-acetyl-β-L-guloside 
• 183878-43-5 p-nitrophenyl 3,6-dideoxy-3-chloro-β-L-guloside 
• 22153-71-5 1-(4-nitrophenyl)-β-L-fucopyranoside 

Relevant academic research and scientific papers

Sugar-modified cytostatics

The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.

Lectin-mediated drug targeting: Discrimination of carbohydrate-mediated cellular uptake between tumor and liver cells with neoglycoconjugates carrying fucose epitopes regioselectively modified in the 3-position

The circumvention of efficient 'carbohydrate traps' in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R1-R3 of the fucose epito