1042703-29-6

Basic information

• Product Name: (2,5-Difluoro-4-hydroxy-phenyl)-acetic acid
• Synonyms: (2,5-Difluoro-4-hydroxy-phenyl)-acetic acid
• CAS NO: 1042703-29-6
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.1282464
• Mol File: 1042703-29-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 323.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.520±0.06 g/cm3(Predicted)
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: (2,5-Difluoro-4-hydroxy-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-Difluoro-4-hydroxy-phenyl)-acetic acid(1042703-29-6)
• EPA Substance Registry System: (2,5-Difluoro-4-hydroxy-phenyl)-acetic acid(1042703-29-6)

Safety Data

• Hazardous Substances Data: 1042703-29-6(Hazardous Substances Data)

Upstream product

• 1000516-77-7 2-(2,5-difluoro-4-methoxyphenyl)acetic acid 
• 1042702-80-6 C₂HF₃O₂*C₁₂H₁₃F₂NO₄ 

Downstream Products

• 1169483-46-8 2-(4-(4-(tert-butylcarbamoyl)-2-nitrophenoxy)-2,5-difluorophenyl)acetic acid 
• 1274666-40-8 C₁₉H₁₈F₂N₂O₆ 
• 1274666-44-2 C₁₉H₁₆F₂N₂O₆ 

Relevant articles and documents

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.