10429-07-9Relevant articles and documents
Conversion of epiandrosterone into 17β-amino-5α-androstane
Merlani,Davitishvili,Nadaraia,Sikharulidze,Papadopulos
, p. 144 - 146 (2004)
A new method for synthesizing 17β-amino-5α-androstane was developed based on tigogenin. The configuration at C-17 was proved by PMR.
METHODS OF ACTIVATING MICROGLIAL CELLS
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Page/Page column 51; 54-55, (2020/02/23)
The present disclosure provides methods of using compositions that inhibit SH2-containing inositol 5'-phosphatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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, (2015/02/02)
Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.