1042907-07-2Relevant articles and documents
Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents
Liu, Ping,Zhu, Shaolong,Li, Peng,Xie, Weijie,Jin, Yongsheng,Sun, Qingyan,Wu, Qiuye,Sun, Peng,Zhang, Yingjun,Yang, Xiaohong,Jiang, Yuanying,Zhang, Dazhi
, p. 3261 - 3265 (2008)
A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4- to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species.
