1042910-06-4Relevant academic research and scientific papers
ZrCl4 as an efficient catalyst for a novel one-pot protection/deprotection synthetic methodology
Singh, Surendra,Duffy, Colm D.,Shah, Syed Tasadaque A.,Guiry, Patrick J.
, p. 6429 - 6432 (2008)
(Chemical Equation Presented) A catalytic quantity of ZrCl4 (20 mol %) was found to be an efficient catalyst for the one-pot esterification and deprotection of (5S,6R)-5,6-diacetoxyoct-7-enoic acid in good yields (44-62%) with a lactone formed as a minor byproduct. ZrCl4 (10-20 mol %) was also sufficient to deprotect 1,3-dioxalane, bis-TBDMS ethers, and diacetate functional groups in excellent yields of up to 93%. ZrCl4 (1-10 mol %) also promoted diol protection as the acetonide in 90% yield and acted as a trans-esterification catalyst for a range of esters.
