1042937-13-2Relevant academic research and scientific papers
Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity
Naydenova, Emilia D.,Todorov, Petar T.,Topashka-Ancheva, Margarita N.,Momekov, Georgi Ts.,Yordanova, Tsvetelina Z.,Konstantinov, Spiro M.,Troev, Kolio D.
, p. 1199 - 1205 (2008)
A series of Cα,α-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 μM.
