1042984-12-2

Basic information

• Product Name: C₂₁H₂₁N₅O
• CAS NO: 1042984-12-2
• Molecular Weight: 359.431
• Mol File: 1042984-12-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁N₅O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁N₅O(1042984-12-2)
• EPA Substance Registry System: C₂₁H₂₁N₅O(1042984-12-2)

Safety Data

• Hazardous Substances Data: 1042984-12-2(Hazardous Substances Data)

Upstream product

• 137766-74-6 (S)-2-phenylpiperazine 
• 1042985-59-0 (2-aminopyridin-3-yl)(6-bromopyridin-2-yl)methanone 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 626-05-1 2,6-Dibromopyridine 

Relevant articles and documents

Structure-based optimization of aminopyridines as PKCθ inhibitors

The identification of a novel series of PKCθ inhibitors and subsequent optimization using docking based on a crystal structure of PKCθ is described. SAR was rapidly generated around an amino pyridine-ketone hit; (6-aminopyridin-2-yl)(2-aminopyridin-3-yl)methanone 2 leading to compound 21 which significantly inhibits production of IL-2 in a mouse SEB-IL2 model.