104306-23-2Relevant academic research and scientific papers
Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran
Kawada, Kosuke,Kitagawa, Osamu,Kobayashi, Yoshiro
, p. 3670 - 3674 (2007/10/02)
3-Trifluoromethylfuran (1) was efficiently synthesized by the reaction of 4-methyloxazole with 3,3,3-trifluoropropyne.Lithiation of 1 with n-butyllithium followed by reaction with an electrophile gave the corresponding 2-substituted 3-trifluoromethylfuran (4).Starting from 2-triethylsilyl-3-trifluoromethylfuran (4a), 2-substituted 4-trifluoromethylfurans (6) were synthesized.Keywords---3-trifluoromethylfuran; 4-methyloxazole; 3,3,3-trifluoropropyne; 2-triethylsilyl-3-trifluoromethylfuran
