104309-93-5

Usage

Chemical class

Synthetic chemical compound

Pharmacological potential

Potential pharmacological properties

Type of compound

Quinone derivative

Structural components

Piperazine ring, benzyl group, chloro group

Potential therapeutic use

Cytotoxic and antitumor activity

Biological activity contributors

Chloro and piperazine groups

Potential applications

Medicinal chemistry and drug discovery

Further research

Needed to fully understand pharmacological properties and potential uses.

Upstream product

• 104309-89-9 3-chloro-2-(piperazin-1-yl)-1,4-naphthoquinone 
• 100-44-7 benzyl chloride 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 

Downstream Products

• 132545-24-5 2-(4-benzylpiperazino)-3-amino-1,4-naphthoquinone 
• 132545-29-0 C₂₁H₁₉N₃O₂ 
• 1355254-94-2 1-benzyl-4-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-1-methylpiperazinium iodide 

Relevant academic research and scientific papers

NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

Provided herein are compounds of (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions and methods involving the inventive compounds for the treatment of proliferative diseases (e.g., cancer (e.g., leukemia, breast cancer, melanoma, metastatic cancer) and diseases associated with inappropriate SET8 activity. Also provided are methods for inhibiting SET8 and methods for labelling SET8.

Synthesis of photoactive 1-methyl-1-R-4-(1,4-dioxo-1,4-dihydronaphthalen-2- yl)piperazinium salts

Photoactive 4-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)piperazinium salts were synthesized by alkylation of 3-chloro-2-(piperazin-1-yl)- and 2-arylamino-3-(4-methylpiperazin-1-yl)-1,4-naphthoquinones. Light sensitivities of materials obtained by adsorption o