10431-96-6

Upstream product

• 63021-45-4 1-(2-naphthoyl)aziridine 
• 613-46-7 2-naphthalenecarbonitrile 
• 141-43-5 ethanolamine 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 2243-83-6 2-naphthaloyl chloride 
• 580-13-2 2-bromonaphthalene 
• 201230-82-2 carbon monoxide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 119072-55-8 tert-butylisonitrile 
• 190733-99-4 1-Bromo-naphthalene-2-carboxylic acid (2-hydroxy-ethyl)-amide 
• 76373-11-0 1-bromo-2-naphthoyl chloride 
• 20717-79-7 1-bromo-2-naphthoic acid 
• 190734-00-0 2-(1-bromo-2-naphthalen-2-yl)-4,5-dihydrooxazole 
• 82408-26-2 N-(2-bromoethyl)-2-naphthamide 

Relevant academic research and scientific papers

Photo-induced Ring-opening Reactions of 1-(2-Naphthoyl)aziridine in Various Solvents

Photoreactions of 1-(2-naphthoyl)aziridine (NAz) have been investigated in various solvents under the deaerated conditions at room temperature.The photo-irradiation of NAz in halogenated hydrocarbons afforded halogen substituted secondary amides such as N-(2-chloroethyl)-2-naphthamide (CENA) or N-(2-bromoethyl)-2-naphthamide (BENA), a ring-expanded isomer of 2-(2-naphthyl)-2-oxazoline (NOz) and the NAz oligomer containing a chlorine atom.Secondary amides such as N-(2-methoxyethyl)-2-naphthamide (MENA) and N-ethyl-2-naphthamide (ENA) were obtained together with NAz oligomer in methanol and 2-propanol, respectively.The formation of N-(2-naphthamide (PENA), phenyl-2-naphthoate (PN) and NAz oligomer was observed in phenol (72 volpercent)-acetonitrile mixture.

Novel chiral biaryl bis(oxazolines)

Novel chiral biaryl bis(oxazoline) have been prepared through a complimentary use of three synthetic methods. The method of choice is determined by the structure of the oxazoline. For bis(oxazolines) containing ethylene spacers between the aromatic ring and the oxazoline groups, a general alkylation procedure based on 2-methyl-2-oxazoline has been developed and found to give very good yields (75-87%) of the desired products. Bis(oxazolines) with the oxazoline moiety attached directly to the aromatic ring were prepared by Ullmann coupling of the appropriate bromoaryl oxazolines. Those containing oxymethylene spacers were prepared by the standard method involving condensation of amino alcohols with the appropriate dicarboxylic acids (84%).

A powerful palladium-catalyzed multicomponent process for the preparation of oxazolines and benzoxazoles

Efficient and convenient three-component couplings of an aryl halide, isocyanide, and an amino alcohol under palladium catalysis provide a range of oxazolines and benzoxazoles in excellent yield.

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.

A 2 - aryl - 2 - oxazoline preparation method

The invention discloses a 2-aryl-2-oxazoline preparation method and belongs to the field of chemistry. According to the method, an aryl-amide compound and 1,2-dichloroethane are reacted for synthesis, and the synthesis reaction is conducted under the alka

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.

Ruthenium(II) 8-quinolinolates: Synthesis, characterization, crystal structure and catalysis in the synthesis of 2-oxazolines

Abstract New octahedral ruthenium(II) complexes (1-4) have been synthesized from the reaction of ruthenium(II) precursors [RuHCl(CO)(EPh3)3] (E = P or As) with the bidentate Schiff base ligands, 2-((2,6-dimethylphenylimino)methyl)quinolin-8-ol (L1) and 2-((2,6-diisopropylphenylimino)methyl)quinolin-8-ol (L2) in ethanol. These complexes have been characterized by elemental analyses, IR, UV-Vis, 1H, 13C and 31P NMR and ESI-Mass spectroscopy. The molecular structure of the complex [RuCl(CO)(PPh3)2(L2)] (2) was determined by single-crystal X-ray diffraction, which reveals a distorted octahedral geometry around ruthenium(II) ion. The catalytic activity of the new complexes was evaluated for the condensation of nitriles with ethanolamine under solvent free conditions. The processes were operative with aromatic and heteroaromatic nitriles and tolerated several substitutional groups. The studies on the effect of substitution over ligands, coligands, reaction time, temperature and catalyst loading were carried out in order to find the best catalyst in this series of complexes and favorable reaction conditions. A probable mechanism for the catalytic condensation of nitrile has also been proposed. The catalyst was recovered and recycled up to five times without significant loss of its activity.

Ruthenium(II) 9,10-phenanthrenequinone thiosemicarbazone complexes: Synthesis, characterization, and catalytic activity towards the reduction as well as condensation of nitriles

The ligands 9,10-phenanthrenequinone-N4-substituted thiosemicarbazones (HL1-3) and their ruthenium(II) complexes were synthesized and characterized by elemental and spectroscopic methods. The ligands are tridentate, monobasic chelating ligands with O, N, and S as the donor sites and are in the thiol form in all the complexes. Catalytic studies showed that all the complexes displayed good catalytic activity towards the reduction of nitriles and also the condensation of nitriles with 2-aminoalcohol under solvent-free conditions.

Polynuclear copper(ii) pyrazolate complexes: Temperature-dependent protonolysis reactions, crystal structures and high catalytic activity toward the condensation of nitriles with 2-aminoalcohol

Reaction of Cu(OAc)2·H2O and 1H-pyrazole-3,5-dicarboxylic acid dimethyl ester (Hdcmpz) in MeOH at room temperature afforded one tetranuclear Cu(ii)/pyrazolate complex [{Cu 2(μ-OAc)2}2(μ-dcmpz)2/