104317-84-2 Usage
Description
Gusperimus, a synthetic derivative of the antitumor antibiotic spergualin
originally isolated from Bacillus laterosporus, was introduced in Japan as a
treatment for accelerated and acute rejection reactions after kidney transplants. It
possesses strong immunosuppressive activity including suppression of
autoimmune disease, prolongation of survival of transplant allografts, induction of
transplant tolerance, reversal of allograft rejection, inhibition of antibody responses,
and suppression of delayed-type hypersensitivity. Although its activity is
comparable to other agents as monotherapy, gusperimus in combination therapy
(such as with cyclosporine A) has been reported to exhibit exceptional activity for
prevention of transplant rejection and to induce long term tolerance. The mechanism
of action appears to be due to inhibition of differentiation and proliferation of effector
cells, including cytotoxic T cells and antibody producing B cells. Gusperimus is also
in clinical trials for the treatment of graft rejection, multiple sclerosis, systemic
lupus, diabetes mellitus, rheumatoid arthritis, nephrosis, and as an anticancer
agent.
Originator
Nippon Kayaku (Japan)
Brand name
Spanidin
Check Digit Verification of cas no
The CAS Registry Mumber 104317-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,3,1 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 104317-84:
(8*1)+(7*0)+(6*4)+(5*3)+(4*1)+(3*7)+(2*8)+(1*4)=92
92 % 10 = 2
So 104317-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H37N7O3/c18-9-7-11-21-10-5-6-12-22-15(26)16(27)24-14(25)8-3-1-2-4-13-23-17(19)20/h16,21,27H,1-13,18H2,(H,22,26)(H,24,25)(H4,19,20,23)
