104338-26-3

Basic information

• Product Name: [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE
• Synonyms: [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE;2-METHOXY-N-METHYL-BENZENEETHANAMINE;OTAVA-BB 7020694233;N-[2-(2-Methoxyphenyl)ethyl]-N-methylamine;2-(2-Methoxyphenyl)-N-methylethanamine
• CAS NO: 104338-26-3
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.234
• Mol File: 104338-26-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE(104338-26-3)
• EPA Substance Registry System: [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE(104338-26-3)

Safety Data

• Hazardous Substances Data: 104338-26-3(Hazardous Substances Data)

Usage

General Description

[2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE is a chemical compound that is composed of a 2-(2-methoxyphenyl)ethyl group bound to a methylamine group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. [2-(2-METHOXYPHENYL)ETHYL](METHYL)AMINE is known for its role in the production of various drugs, such as antihistamines and antidepressants. It is also used in chemical reactions as a reagent or building block for the synthesis of other organic compounds. Additionally, it is important to handle this chemical with caution as it can be hazardous if not used properly.

Upstream product

• 2045-79-6 o-methoxy-2-phenylethylamine 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 258882-54-1 N-(methoxycarbonyl)-2-(2-methoxyphenyl)ethylamine 
• 131699-15-5 N-(t-Butyloxycarbonyl)-2-(2-methoxyphenyl)-ethylamine 
• 59734-18-8 3-(2-methoxy-phenyl)-propionic acid amide 

Downstream Products

• 69226-64-8 N-(2-methoxy-phenethyl)-N-methyl-urea 
• 154585-18-9 2-(2-methylamino-ethyl)-phenol 
• 1282042-14-1 C₂₀H₂₂N₄O₂ 

Relevant articles and documents

Palladium-Catalyzed C(sp2)-H Olefination of Free Primary and Secondary 2-Phenylethylamines: Access to Tetrahydroisoquinolines

A rapid construction of THIQs by a Pd(II)-catalyzed C(sp2)-H olefination of free primary and secondary 2-phenylethylamines with high step- and atom-economy was reported. Notably, no substituent was required at the α-position to the amino group of the 2-phenylethylamines. The substrate scope was broad, and the reaction could also be applied to generate THIQs from the biologically active molecules such as the drug molecule baclofen and phenylalanine ester.

Iron-Catalyzed Intramolecular C—H Amidation of N-Benzoyloxyureas

A redox-neutral Fe-catalyzed intramolecular C—H amidation of N-benzoyloxyureas is described. This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene prec

Selective N-methylation of primary aliphatic amines with dimethyl carbonate in the presence of alkali cation exchanged Y-faujasites

The N-methylation of aliphatic amines [XC6H4(CH 2)nNH2; n=1, X=H (1a), o-MeO (1b), p-MeO (1c); n=2, X=H (2a), o-MeO (2b); 1d: PhCH(Me)NH2] with dimethyl carbonate (DMC) is efficiently catalysed by NaY faujasite: on condition that CO 2 (a co-product of the reaction) is carefully removed, N-methyl- and N,N-dimethyl-amines (RNHMe and RNMe2) are obtained in good overall yields (70-90%). Otherwise, in the presence of CO2, carbamates (RNHCO2Me) form competitively to a large extent. The reaction probably proceeds through a BAl2 displacement of the amine on DMC.