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HISTATIN-5 is a naturally occurring antimicrobial peptide present in human saliva, which is instrumental in safeguarding the oral cavity from microbial infections. It exhibits potent antifungal properties, particularly against Candida albicans, the fungus responsible for oral infections like oral thrush. HISTATIN-5 operates by disrupting the fungal cell membrane, leading to its demise. Besides its antifungal capabilities, it also has antibacterial properties and contributes to the maintenance of oral microbiota balance. Research indicates that HISTATIN-5 could have therapeutic potential in treating oral candidiasis and other oral infections.

104339-66-4

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Basic information
1. Product Name: HISTATIN-5
2. Synonyms: DSHAKRHHGYKRKFHEKHHSHRGY;H-ASP-SER-HIS-ALA-LYS-ARG-HIS-HIS-GLY-TYR-LYS-ARG-LYS-PHE-HIS-GLU-LYS-HIS-HIS-SER-HIS-ARG-GLY-TYR-OH;HISTATIN-5;HISTATIN 5 (HUMAN);ASP-SER-HIS-ALA-LYS-ARG-HIS-HIS-GLY-TYR-LYS-ARG-LYS-PHE-HIS-GLU-LYS-HIS-HIS-SER-HIS-ARG-GLY-TYR;Histatin 5【human parotid saliva】;L-Asp-L-Ser-L-His-L-Ala-L-Lys-L-Arg-L-His-L-His-Gly-L-Tyr-L-Lys-L-Arg-L-Lys-L-Phe-L-His-L-Glu-L-Lys-L-His-L-His-L-Ser-L-His-L-Arg-Gly-L-Tyr-OH
3. CAS NO:104339-66-4
4. Molecular Formula: C133H195N51O33
5. Molecular Weight: 3036.29
6. EINECS: N/A
7. Product Categories: Peptide
8. Mol File: 104339-66-4.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: −20°C
8. Solubility: N/A
9. CAS DataBase Reference: HISTATIN-5(CAS DataBase Reference)
10. NIST Chemistry Reference: HISTATIN-5(104339-66-4)
11. EPA Substance Registry System: HISTATIN-5(104339-66-4)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: 22-24/25
4. WGK Germany: 3
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 104339-66-4(Hazardous Substances Data)

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104339-66-4 Usage

Uses

Used in Oral Health Care:
HISTATIN-5 is used as an antimicrobial agent for preventing and treating oral infections, particularly candidiasis, by inhibiting the growth of the fungus Candida albicans and maintaining the oral microbiota balance.
Used in Pharmaceutical Industry:
HISTATIN-5 is used as a therapeutic agent for the treatment of oral candidiasis and other oral infections, leveraging its antifungal and antibacterial properties to combat microbial overgrowth and restore oral health.
Used in Dental Care Products:
HISTATIN-5 is used as an active ingredient in dental care products, such as mouthwashes and toothpastes, to enhance their antimicrobial efficacy and support oral hygiene by preventing the growth of harmful microorganisms in the mouth.

Check Digit Verification of cas no

The CAS Registry Mumber 104339-66-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,3,3 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 104339-66:
(8*1)+(7*0)+(6*4)+(5*3)+(4*3)+(3*9)+(2*6)+(1*6)=104
104 % 10 = 4
So 104339-66-4 is a valid CAS Registry Number.

InChI:InChI=1/C133H195N51O33/c1-71(164-120(206)96(46-76-54-146-65-158-76)181-128(214)103(62-185)183-110(196)84(138)52-108(193)194)109(195)167-86(18-5-9-35-134)113(199)172-91(24-15-41-154-133(143)144)118(204)178-99(49-79-57-149-68-161-79)125(211)176-95(45-75-53-145-64-157-75)112(198)156-60-105(189)165-93(43-73-25-29-82(187)30-26-73)121(207)173-87(19-6-10-36-135)114(200)171-90(23-14-40-153-132(141)142)115(201)169-88(20-7-11-37-136)116(202)175-94(42-72-16-3-2-4-17-72)122(208)179-97(47-77-55-147-66-159-77)124(210)174-92(33-34-107(191)192)119(205)170-89(21-8-12-38-137)117(203)177-100(50-80-58-150-69-162-80)126(212)180-101(51-81-59-151-70-163-81)127(213)184-104(63-186)129(215)182-98(48-78-56-148-67-160-78)123(209)168-85(22-13-39-152-131(139)140)111(197)155-61-106(190)166-102(130(216)217)44-74-27-31-83(188)32-28-74/h2-4,16-17,25-32,53-59,64-71,84-104,185-188H,5-15,18-24,33-52,60-63,134-138H2,1H3,(H,145,157)(H,146,158)(H,147,159)(H,148,160)(H,149,161)(H,150,162)(H,151,163)(H,155,197)(H,156,198)(H,164,206)(H,165,189)(H,166,

104339-66-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name	HISTATIN-5

1.2 Other means of identification

Product number	-
Other names	DSHAKRHHGYKRKFHEKHHSHRGY

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104339-66-4 SDS

104339-66-4Upstream product

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104339-66-4Related news

HISTATIN-5 (cas 104339-66-4) induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisae08/04/2019

SummaryBackgroundCandidiasis is a major opportunistic fungal infection in humans. The low number of antifungal drugs available to treat Candida infections and the increasing incidence of multidrug resistant (MDR) strains point to an urgent need of identifying new therapeutic options. The role of...detailed

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