1043446-41-8Relevant articles and documents
Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer
Yoshino, Hitoshi,Sato, Haruhiko,Shiraishi, Takuya,Tachibana, Kazutaka,Emura, Takashi,Honma, Akie,Ishikura, Nobuyuki,Tsunenari, Toshiaki,Watanabe, Miho,Nishimoto, Ayako,Nakamura, Ryo,Nakagawa, Toshito,Ohta, Masateru,Takata, Noriyuki,Furumoto, Kentaro,Kimura, Kazuya,Kawata, Hiromitsu
, p. 8150 - 8157 (2011/02/22)
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of castration-resistant prostate cancer. Since CH4933468, which we reported previously, had a problem wit