1043451-96-2Relevant academic research and scientific papers
An improved protocol for the Prins desymmetrisation of cyclohexa-1,4-dienes
Butters, Michael,Elliott, Mark C.,Hill-Cousins, Joseph,Paine, James S.,Westwood, Alexander W.J.
, p. 4446 - 4448 (2008/12/21)
Improved conditions are reported for the Prins-pinacol rearrangement of cyclohexa-1,4-diene-derived acetals. The use of triflic acid gives particularly clean reaction, resulting in a mixture of regioisomers in an approximately 10:1 ratio. A tethered version of this reaction is also reported, giving a tricyclic compound with the same stereochemistry as the core of the cladiellin diterpenes.
