1043455-56-6

Basic information

• Product Name: C₁₉H₂₉NO₂
• Synonyms: C₁₉H₂₉NO₂
• CAS NO: 1043455-56-6
• Molecular Weight: 303.445
• Mol File: 1043455-56-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₉NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₉NO₂(1043455-56-6)
• EPA Substance Registry System: C₁₉H₂₉NO₂(1043455-56-6)

Safety Data

• Hazardous Substances Data: 1043455-56-6(Hazardous Substances Data)

Upstream product

• 31828-71-4 RS-mexiletine 
• 24303-61-5 2,2,3,3-tetramethylcyclopropanecarbonyl chloride 

Relevant articles and documents

Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives

As part of our ongoing research on potential new antiepileptic drugs (AEDs), a series of tetramethylcyclopropanecarboxamide derivatives containing benzene ring were designed, synthesized, and evaluated for anticonvulsant activities in the murine maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) seizure tests. The most potent compound emerging from this study was N-(2,2,3,3-tetramethylcyclopropanecarboxamide)-p-phenyl-sulfonamide (21), possessing an ED50 value of 26 mg/kg in the rat-MES test and a remarkable PI (PI = TD50/ED50) value above 19. The better anticonvulsant potency of compound 21 and its wider safety margin compared to valproic acid (VPA) and zonisamide make it a potential candidate to become a new AED second-generation to VPA.