1043580-06-8

Basic information

• Product Name: 3-fluoro-4-({[(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]carbonothioyl}amino)benzene sulfonamide
• CAS NO: 1043580-06-8
• Molecular Weight: 403.522
• Mol File: 1043580-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-fluoro-4-({[(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]carbonothioyl}amino)benzene sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-({[(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]carbonothioyl}amino)benzene sulfonamide(1043580-06-8)
• EPA Substance Registry System: 3-fluoro-4-({[(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]carbonothioyl}amino)benzene sulfonamide(1043580-06-8)

Safety Data

• Hazardous Substances Data: 1043580-06-8(Hazardous Substances Data)

Upstream product

• 860314-27-8 3-fluoro-4-isothiocyanato-benzenesulfonamide 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 

Relevant articles and documents

Carbonic anhydrase inhibitors: Design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes

A series of spin-labeled sulfonamides incorporating TEMPO moieties were synthesized by a procedure involving the formation of a thiourea functionality between the benzenesulfonamide and free radical fragment of the molecules. The new compounds were tested as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and showed efficient inhibition of the physiologically relevant isozymes hCA II and hCA IX (hCA IX being predominantly found in tumors) and moderate to weak inhibitory activity against hCA I. Some derivatives were also selective for inhibiting the tumor-associated isoform over the cytosolic one CA II, and presented significant changes in their ESR signals when complexed to the enzyme active site, being interesting candidates for the investigation of hypoxic tumors overexpressing CA IX by ESR techniques, as well as for imaging/treatment purposes.