1043882-84-3Relevant academic research and scientific papers
BICYCLIC DERIVATIVES AS EP4 AGONISTS
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Page/Page column 38; 40, (2008/12/07)
The present invention relates to a compound of formula (I) including any stereochemical isomeric form thereof, wherein A represents a 5 or 6-membered aromatic optionally substituted heterocycle containing 1, 2 or 3 heteroatoms; ring E represents a partially saturated or aromatic 5-membered heterocycle wherein the dotted lines represent an optional double bond and wherein B, C and D each independently represent CH2, CH, N, NH, S or O and F represents N or C, provided that the 5-membered ring contains 1, 2 or 3 heteroatoms; X represents a direct bond or C1-4alkanediyl; Y represents N or CH; R1 represents hydrogen or fluoro; R2 represents hydrogen, halo, cyano, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl or C1-6alkylcarbonylamino; R3 represents hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, nitro, amino or mono-or di(C1-6alkyl)amino; n represents an integer of value 1, 2 or 3; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a disease by activating the EP4 receptor.
