104389-67-5

Upstream product

• 29892-37-3 chloro(dimethylsulfide) gold(I) 
• 119072-54-7 2,6-dimethylphenyl isonitrile 
• 39929-21-0 (tetrahydrothiophene)gold(I) chloride 
• 1354651-03-8 [Pd(C,N-C(=NXy)C₆H₄(C(Me)=NOH)-2)Cl(CNXy)] 
• 618-36-0 rac-methylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 400849-86-7 [Au(2-HSPy)(2,6-Me₂C₆H₃NC)]OTf 
• 400849-82-3 [Au(2-SQn)(2,6-Me₂C₆H₃NC)] 
• 400849-80-1 [Au(4-SC₆H₄CO₂H)(2,6-Me₂C₆H₃NC)] 
• 219789-02-3 ((CH₃)2C₆H₃NC)AuI 
• 1013030-05-1 [Au((aza-15-crown-5)dithiocarbamate)(2,6-dimethylphenyl isocyanide)] 
• 1013029-90-7 [Au((aza-15-crown-5)dithiocarbamate)]6 

Relevant academic research and scientific papers

A complex of gold(I) benzenethiolate with isocyanide: Synthesis and crystal and molecular structures

2,6-Dimethylphenyl isocyanide forms complexes with gold(I) chloride (complex 4) and gold(I) benzenethiolate (complex 5) but forms no stable complexes with gold alkanethiolates. A reaction of complex 5 with tetramethylthiuram disulfide yields gold(I) dimethyldithiocarbamate. Stable gold(III) derivatives cannot be obtained in such a way. Shortened intermolecular Au...Au contacts in complexes 4 and 5 (X-ray diffraction) suggest the presence of "aurophilic" interactions in them.

Synthesis of Bioactive N-Acyclic Gold(I) and Gold(III) Diamino Carbenes with Different Ancillary Ligands

A series of gold(I) and gold(III) N-acyclic diamino carbene (ADC) complexes with different ancillary ligands have been synthesized. The chloride carbene derivatives [Au{C(NHR)(NHCH2py)}Cl] (R = Cy, R = naphthyl, R = xylyl) have been obtained by reaction of 2-picolylamine with the corresponding [AuCl(CNR)]. The gold(I) thiolate derivatives [Au{C(NHR)(NHCH2py)}(Spy)] were prepared by reaction of the chlorido complexes with 2-mercaptopyridine (2-HSpy) in presence of potassium carbonate. The phosphane derivative [Au(pyCH2NH2)(PPh3)](OTf) was obtained by reaction of freshly prepared [Au(OTf)(PPh3)] with 2-picolylamine. The phosphane-carbene complexes [Au{C(NHR)(NHCH2py}(PPh3)](OTf) were obtained from the reaction of picolylamino species with the isocyanide. The gold(III) derivative cis-[Au(C6F5)2(pyCH2NH2)](ClO4) was obtained by the reaction of 2-picolylamine with freshly [Au(C6F5)2(Et2O)2](ClO4). The reaction of the former with CNCy led to complex cis-[Au(C6F5)2{C(NHCy)(NHCH2py)}]ClO4 by a nucleophilic attack of the isocyanide to the amine ligand, thus producing a bidentate C,N acyclic carbene ligand. Cytotoxic studies against the tumor human cell lines Jurkat (T-cell leukaemia), MiaPaca2 (pancreatic carcinoma), A549 (lung carcinoma) and MDA-MB-231 (breast carcinoma) showed moderate to good cytotoxic activity for some of the complexes.

Room-Temperature Hydration of Alkynes Catalyzed by Different Carbene Gold Complexes and their Precursors

The room-temperature hydration of alkynes catalyzed by NHC-gold(I) (NHC=N-heterocyclic carbene), NAC-gold(I) (NAC=nitrogen acyclic carbene), and isocyanide gold(I) complexes was investigated carefully in the presence of different weakly coordinating anion

Addition of: N -nucleophiles to gold(III)-bound isocyanides leading to short-lived gold(III) acyclic diaminocarbene complexes

Reaction of [AuCl3(CNR1)] (R1 = Xyl, Cy, (S)-CHMePh) with amines unexpectedly proceeds via the redox pathway giving gold(i)-isocyanides and imines, while the addition of benzophenone hydrazone to the isocyanide ligand in [

Hydration of alkynes at room temperature catalyzed by gold(I) isocyanide compounds

An effective method using gold(I) isocyanide complexes as catalysts for the transformation of various alkynes to the corresponding ketones is successfully developed. The hydration process proceeds smoothly at room temperature with quite high yield (up to 99%). The catalytic center is the isocyanide-Au(I)+ cation. Further theoretical research reveals a direct hydration mechanism by H2O, and the rate-determining step has an energy barrier of 23.7 kcal mol?1. These results show a good example to reduce unnecessary steps and achieve milder reaction conditions at the same time for the hydration of alkynes.

A systematic study on the synthesis, reactivity and structure of ortho-palladated aryloximes, including the first cyclopalladated aryloximato and iminoaryloxime complexes

Complexes [Pd{C,N-Ar{C(Me)NOH}-2}(μ-Cl)]2 (1) with Ar = C6H4, C6H3NO2-5 or C 6H(OMe)3-4,5,6, were obtained from the appropriate oxime, Li2[PdCl4]

Gold(I)-isocyanide and gold(I)-carbene complexes as substrates for the laser decoration of gold onto ceramic surfaces

Gold-isocyanide complexes XAu(RNC) (X = halide, pseudohalide, R = alkyl, aryl) and water soluble gold-carbene complexes XAuC(NHPh)[MeN(CH 2CH2O)nMe] (X = Cl, n = 1-11) have been prepared and evaluated as substrates for the direct laser writing of gold decoration onto ceramics. The Royal Society of Chemistry 2007.

Preparation and structural characterisation of isocyanide gold(I) nitrates, [Au(NO3)(CNR)] (R = Et, But or C6H3Me2-2,6); new auriophilic motifs

The first examples of isocyanide gold(I) nitrates, [Au(NO3)(CNR)] (R = Et, But or C6H3Me2-2,6) have been prepared from the corresponding chlorides and AgNO3. Full characterisation included crystal structure determinations for each example. The structures of the analogous compounds [AuCl(CNR)] (R = Et or C6H3Me2-2,6) were also determined for comparison. All species show Au ... Au interactions in the solid state, but with different modes of aggregation; [AuCl(CNEt)] and [Au(NO3)(CNBut)] have infinite zigzag chains, [AuCl-(CNC6H3Me2-2,6)] has a 'broken' chain of tetrameric units, [Au(NO3)(CNEt)] has a linked chain of tetrameric units, while [Au(NO3)(CNC6H3Me2-2,6)] has a highly compressed chain. In each instance the Au ... Au interactions for [Au(NO3)(CNR)] are shorter than for the analogous [AuCl(CNR)], suggesting NO3- enhances these secondary bonds. This is in direct contrast to previous theoretical predictions. The structure of the solvated ionic compound [Au(CNC6H3Me2-2,6)2]NO3 has also been determined.