1043963-48-9Relevant academic research and scientific papers
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli
Aberg, Veronica,Das, Pralay,Chorell, Erik,Hedenstroem, Mattias,Pinkner, Jerome S.,Hultgren, Scott J.,Almqvist, Fredrik
supporting information; scheme or table, p. 3536 - 3540 (2009/04/05)
Ring-fused 2-pyridones, termed pilicides, are small synthetic compounds that inhibit pilus assembly in uropathogenic Escherichia coli. Their biological activity is clearly dependent upon a carboxylic acid functionality. Here, we present the synthesis and
