104405-56-3

Upstream product

• 4797-43-7 6-chloro-4-phenyl-2-quinazolinone 
• 136440-60-3 (E)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 136440-59-0 (Z)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 

Downstream Products

• 108959-10-0 10-Chloro-8-phenyl-1,6,7,12b-tetraaza-benzo[c]phenanthren-5-one 
• 104425-84-5 7-Chloro-9-phenyl-1,3,4a,10-tetraaza-phenanthrene-2,4-dione 
• 108959-08-6 2-Chloro-N-(6-chloro-4-phenyl-quinazolin-2-yl)-nicotinamide 

Relevant academic research and scientific papers

Antiarrhythmic active amidinohydrazones of substituted benzophenones. Part 5: Investigations on the stability of (Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate in solution

The aqueous solution of the title compound can be used for injection for one year if it is stored at room temperature and under light protection. Under these conditions 8% of the E-isomer are produced. The reaction is reversible at day light. Red coloured products of decomposition are formed by long lasting influence of light. At higher temperatures or at sterilisation several products of decomposition are formed which structure is elucidated. For these decomposition a scheme is proposed.

SYNTHESIS OF 5H-DIPYRIDOPYRIMIDIN-5-ONE AND 5-H-PYRIDOPYRIMIDOQUINAZOLIN-5-ONES

α-Amino-N-heteroarenes on cyclocondensation with 2-chloropyridine-3-carboxylic acid chloride afford the title compounds 4 and 7.Although compound 4 is obtained in one-pot while compound 7 is formed via its amide intermediate 6.