104415-92-1

Basic information

• Product Name: 2-Chloro-4-methylnaphthalene
• Synonyms: 2-Chloro-4-methylnaphthalene
• CAS NO: 104415-92-1
• Molecular Formula: C11H9Cl
• Molecular Weight: 176.64216
• Mol File: 104415-92-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-4-methylnaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methylnaphthalene(104415-92-1)
• EPA Substance Registry System: 2-Chloro-4-methylnaphthalene(104415-92-1)

Safety Data

• Hazardous Substances Data: 104415-92-1(Hazardous Substances Data)

Upstream product

• 4523-46-0 4-methyl-2-naphthalenamine 
• 557-98-2 2-chloropropene 
• 3883-13-4 2,2,2-trichloroethylbenzene 
• 41037-13-2 3-nitro-1-methylnaphthalene 

Downstream Products

• 58782-64-2 3-chloro-1-naphthaldehyde 

Relevant articles and documents

Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations

The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide with a tertiary-alkyl organometallic reagent (or the precursor components thereof) in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternative embodiment of the present invention, nickel(0) compounds are prepared from nickel(II) compounds by contacting a nickel(II) compound with a combination of an organophosphine and a bidentate nitrogen-containing coordinating ligand, and a tertiary-alkyl organometallic reagent (or the precursor components thereof) in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of nickel(0) compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.