1044222-39-0Relevant articles and documents
Asymmetric synthesis of (trifluoromethyl)piperidines: Preparation of highly enantioenriched α′-(trifluoromethyl)pipecolic acids
Jatoi, Wahid B.,Bariau, Annabelle,Esparcieux, Cécile,Figueredo, Gilles,Troin, Yves,Canet, Jean-Louis
, p. 1305 - 1308 (2008)
The first asymmetric synthesis of (trifluoromethyl)pipecolic acids is reported. The synthetic strategy involves as key step an intramolecular Mannich reaction of a homochiral α-Tfm-β-amino ketal, prepared with a high stereoselectively in four steps from a fluoral hemiacetal. Georg Thieme Verlag Stuttgart.