1044231-66-4Relevant academic research and scientific papers
Direct arylation of thiophenes via palladium-catalysed C-H functionalisation at low catalyst loadings
Battace, Ahmed,Lemhadri, Mhamed,Zair, Touriya,Doucet, Henri,Santelli, Maurice
, p. 2507 - 2516 (2008/09/19)
Palladium associated with cis,cis,cis-1,2,3,4- tetrakis(diphenylphosphinomethyl)cyclopentane (Tedicyp) was found to promote the direct 2-arylation of a variety of thiophene derivatives via C-H functionalisation in good yields using very low catalyst loadings. Electron-deficient, electron-excessive or sterically-congested aryl bromides are tolerated. Moreover, several substituents on the aryl bromide or thiophene derivatives such as acetyl, formyl, nitrile, nitro, ester, methoxy, fluoro or trifluoromethyl are tolerated. The most reactive aryl bromides were coupled with thiophenes derivatives using as little as 0.1-0.01 mol% catalyst.
THIOPHENE DERIVATIVE PPAR MODULATORS
-
Page 41-42; 68; 75-76, (2008/06/13)
The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.
