1044235-99-5Relevant academic research and scientific papers
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles
McAtee, John J.,Dodson, Jason W.,Dowdell, Sarah E.,Erhard, Karl,Girard, Gerald R.,Goodman, Krista B.,Hilfiker, Mark A.,Jin, Jian,Sehon, Clark A.,Sha, Deyou,Shi, Dongchuan,Wang, Feng,Wang, Gren Z.,Wang, Ning,Wang, Yonghui,Viet, Andrew Q.,Yuan, Catherine C.K.,Zhang, Daohua,Aiyar, Nambi V.,Behm, David J.,Carballo, Luz H.,Evans, Christopher A.,Fries, Harvey E.,Nagilla, Rakesh,Roethke, Theresa J.,Xu, Xiaoping,Douglas, Stephen A.,Neeb, Michael J.
, p. 3716 - 3719 (2008)
Lead compound 1 was successfully redesigned to provide compounds with improved pharmacokinetic profiles for this series of human urotensin-II antagonists. Replacement of the 2-pyrrolidinylmethyl-3-phenyl-piperidine core of 1 with a substituted N-methyl-2-
