1044243-97-1

Usage

Biological activity

Potential antifolate agent

Type of compound

Pteridine derivative

Biological activities of pteridines

Anti-inflammatory, antiviral, anticancer

Specific groups present in the compound

Chloro group and pyridinylmethyl group

Need for further research

To fully understand pharmacological and toxicological properties

Upstream product

• 55583-59-0 2,5-diamino-4,6-dichloropyrimidine 
• 1020981-13-8 methyl 2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylamino)acetate 
• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 
• 130000-78-1 (4-methoxy-3,5-dimethylpyridin-2-yl)methanamine 
• 1179895-66-9 ethyl 2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylamino)acetate 
• 1044243-98-2 methyl 2-[(2-amino-6-chloro-5-nitro-pyrimidin-4-yl)-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]amino]acetate 

Relevant academic research and scientific papers

BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES

The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors

A new series of compounds, 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones, have been designed and identified as potent and selective inhibitors of Hsp90. These compounds demonstrated nanomolar

5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS

The present invention relates to compounds that inhibit HSP90 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as for treatment of solid tumours.