1044255-22-2Relevant academic research and scientific papers
Design, synthesis and evaluation of potent thymidylate synthase X inhibitors
Esra Oenen,Boum, Yap,Jacquement, Claire,Spanedda, Maria Vittoria,Jaber, Nada,Scherman, Daniel,Myllykallio, Hannu,Herscovici, Jean
scheme or table, p. 3628 - 3631 (2009/04/06)
Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these molecules revealed two distinct classes of compounds that inhibit ThyX with submicromolar concentrations, which could lead, after optimization, to effective inhibitors with potential biomedical interest.
