104426-43-9

Upstream product

• 1009-14-9 phenyl butyl ketone 
• 64-19-7 acetic acid 
• 49851-31-2 α-bromovalerophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 4250-81-1 1-phenyl-1-pentyne 
• 104426-43-9 1-oxo-1-phenylpentan-2-yl acetate 

Downstream Products

• 97551-17-2 (R)-(+)-2-hydroxy-1-phenyl-1-pentan-1-one 

Relevant academic research and scientific papers

Sulfur-mediated difunctionalization of internal and terminal alkynes for the synthesis of α-acetoxy ketones

The sulfur-mediated difunctionalization of alkynes is reported to give α-acetoxy ketones in a one-pot operation under mild conditions with 19–92% yield. By using wet potassium acetate as both the aqueous base and nucleophilic reagent, both terminal alkynes and internal alkynes could be converted into the α-acetoxy ketone products.

Redox catalysis of halide ion for formal cross-dehydrogenative coupling: Bromide ion-catalyzed direct oxidative α-acetoxylation of ketones

A novel catalytic approach for formal cross-dehydrogenative coupling using the redox property of bromide ion is reported. Simple bromide salts MBr can work as catalyst for direct oxidative α-acetoxylation of ketones.

Polymer-supported synthesis of α- and β-hydroxyketones through the formation of 1,3-dithiane intermediates

The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones, α,β- unsaturated ketones and oxiranes, and cleavage of

Iodobenzene-catalyzed α-acetoxylation of ketones. In situ generation of hypervalent (diacyloxyiodo)benzenes using m-chloroperbenzoic acid

Reported here for the first time is the iodobenzene-catalyzed α-oxidation of ketones, in which diacyloxy(phenyl)-λ3-iodanes generated in situ act as real oxidants of ketones and m-chloroperbenzoic acid serves as a terminal oxidant. Oxidation of a ketone with m-chloroperbenzoic acid in acetic acid in the presence of a catalytic amount of iodobenzene, BF3·Et2O, and water at room temperature under argon affords an α-acetoxy ketone in good yield. p-Methyl- and p-chloroiodobenzene also serve as efficient catalysts in this direct oxidation. We found that when the reaction was carried out in the absence of a catalytic amount of iodobenzene, Baeyer-Villiger oxidation of a ketone took place. It is noted that use of water and BF3·Et2O is crucial to the success of this α-acetoxylation. Copyright

Preparation of Optically Active α-Acetoxyacylophenones via Enzyme Mediated Hydrolysis

Microorganisms that hydrolyzes α-acetoxyacylophenones were screened, and it was found that Pichia miso IAM 4682, a type culture belonging to yeast, gave the best results.The esterase of this microbe hydrolyzed (R)-acetates in a highly enantioselective manner.