10443-86-4

Basic information

• Product Name: 1H-pyrimidine-2,4-diselone
• Synonyms: 1H-pyrimidine-2,4-diselone
• CAS NO: 10443-86-4
• Molecular Formula: C4H4N2Se2
• Molecular Weight: 238
• Mol File: 10443-86-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1H-pyrimidine-2,4-diselone(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrimidine-2,4-diselone(10443-86-4)
• EPA Substance Registry System: 1H-pyrimidine-2,4-diselone(10443-86-4)

Safety Data

• Hazardous Substances Data: 10443-86-4(Hazardous Substances Data)

Usage

Class

Organic diselenides (compounds containing a selenide group bonded to two organic moieties)

Type

Pyrimidine derivative (heterocyclic ring with a diselenide group at the 2 and 4 positions)

Rarity

Relatively rare and unusual compound

Potential applications

Organic synthesis, coordination chemistry, antioxidant, and medicinal properties (requires further research for full understanding of potential uses and effects)

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 

Relevant articles and documents

Chalcogen containing heterocyclic scaffolds: New hybrids with antitumoral activity

In this work, 27 novel hybrid derivatives containing diverse substituents with chalcogen atoms (selenium or sulfur) and several active heterocyclic scaffolds have been synthesized. Compounds were tested against two human cancer cells lines (MCF7 and PC-3) and a normal human mammary epithelial cell line (184B5) in order to determine their activity and selectivity against malignant cells. Ten compounds showed GI50values below 10?μM in at least one of the cancer cell lines and six of them exhibited a selectivity index higher than 9. In general, selenium-containing compounds were more active than their corresponding sulfur analogs but we found some thiocyanate derivatives with comparable or higher activity and selectivity. Among the different substituents, the seleno- and thio-cyanate groups showed the most promising results. On the basis of their potent activity and high selectivity index, compounds 7e and 8f (containing a thiocyanate and a selenocyanate group, respectively) were selected for further biological evaluation. Both the compounds induced caspase-dependent cell death and cell cycle arrest in G2/M phase. In addition, these compounds do not violate any of the Lipinski's Rule of Five and thus possess good potential to become drugs, compound 7e being particularly promising.