104447-56-5

Basic information

• Product Name: 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid methyl ester
• Synonyms: 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid methyl ester
• CAS NO: 104447-56-5
• Molecular Weight: 456.541
• Mol File: 104447-56-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid methyl ester(104447-56-5)
• EPA Substance Registry System: 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid methyl ester(104447-56-5)

Safety Data

• Hazardous Substances Data: 104447-56-5(Hazardous Substances Data)

Upstream product

• 826-55-1 2-methyl-2-phenylpropionic acid 
• 104446-67-5 methyl 4-<(6-aminoindol-1-yl)methyl>-3-methoxybenzoate 
• 70264-94-7 methyl 4-(bromomethyl)-3-methoxybenzoate 
• 7151-68-0 3-methoxy-p-toluic acid 
• 104437-17-4 methyl 3-methoxy-4-<(6-nitroindol-1-yl)methyl>benzoate 
• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 

Downstream Products

• 104448-00-2 3-Methoxy-4-[6-(2-methyl-2-phenyl-propionylamino)-indol-1-ylmethyl]-benzoic acid 

Relevant articles and documents

Evolution of a Series of Peptidoleukotriene Antagonists: Synthesis and Structure-Activity Relationships of 1,6-Disubstituted Indoles and Indazoles

A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes.A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents.The corresponding indazoles were equipotent.These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.