1044589-67-4

Upstream product

• 1044589-66-3 (2R,3R)-1-bis(hydroxymethyl)-1,2-O-isopropylidene-4-triphenylmethyloxy-butane-1,2,3-triol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1044589-70-9 iso-2'-C-methyl-2',3'-O-isopropylidene-5'-O-triphenylmethyl-6-O-(methoxyethyl)-guanosine 
• 1044589-72-1 iso-2'-C-methyl-2',3'-O-isopropylidene-5'-O-triphenylmethyl-uridine 
• 1044589-68-5 iso-2'-C-methyl-2',3'-O-isopropylidene-5'-O-triphenylmethyl-adenosine 

Relevant academic research and scientific papers

Synthesis of 2′-C-methyl-branched isonucleosides

Novel regioisomers of 2′-methyl-branched nucleosides were designed and synthesized to mimic potent anti-viral drugs like Valopicitabine. The short and efficient synthesis of the targets involves a one-pot tosylation/cyclization step that leads to an activated furan scaffold on which the isonucleosides were built.