104468-72-6Relevant academic research and scientific papers
NITROOLEFINS. I. A NEW AND CONVENIENT ACCESS TO INDOLIZINES AND PYRAZOLOPYRIDINES USING 1-NITRO-2-(PHENYLTHIO>ETHYLENE
Tominaga, Yoshinori,Ichihara, Yuichi,Hosomi, Akira
, p. 2345 - 2348 (1988)
1-Nitro-2-(phenylthio)ethylene (1) reacts with a variety of N-ylides and N-imines (pyridinium, isoquinolinium, quinolinium, phthalazinium N-ylides and N-imines) in the presence of triethylamine to give the corresponding fused pyrrole and pyrazole derivatives (indolizines, pyrroloisoquinoline, pyrrolophthalazine, pyrazolopyridine, pyrazoloquinoline, and pyrazoloisoquinoline) along with the corresponding 1-nitropyrrolopyridines and 1-nitropyrazolopyridines, respectively, in moderate yields.
Chemical Compounds
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Paragraph 1084, (2017/01/19)
Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative disease such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer.
