10447-38-8 Usage
Description
1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride, commonly known as AH-7921, is a synthetic opioid analgesic drug characterized by its selective agonist activity at the μ-opioid receptor. It has been utilized in scientific research as a reference compound for evaluating the specificity of opioid receptors. AH-7921 exhibits potent pain-relieving properties and respiratory depression in animal studies, akin to other opioids, but also induces adverse effects such as sedation, itching, and constipation. Due to its potential for abuse and dependence, it has been classified as a controlled substance.
Uses
Used in Scientific Research:
1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride is used as a reference compound in scientific research for testing the specificity of opioid receptors. It aids in understanding the mechanisms of action and the therapeutic potential of opioids.
Used in Pain Management Research:
In the field of pain management, 1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride is used as an analgesic agent for studying the efficacy of pain relief. Its ability to produce effective pain relief in animal studies makes it a valuable tool for investigating new approaches to pain management.
Used in Respiratory Depression Studies:
1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride is utilized in respiratory depression studies to explore the side effects of opioid use. Its known respiratory depressant effects provide insights into the risks associated with opioid medications.
Used in Drug Abuse and Dependence Research:
In the context of drug abuse and dependence research, 1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride serves as a model compound to investigate the potential for abuse and the development of dependence on synthetic opioids. This research is crucial for understanding and addressing the public health concerns related to opioid misuse.
Used in Pharmaceutical Development:
Although classified as a controlled substance, 1-Azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol hydrochloride may still be used in the development of new pharmaceuticals with improved safety profiles. Its study can contribute to the design of opioids with reduced abuse potential and dependence liabilities.
Check Digit Verification of cas no
The CAS Registry Mumber 10447-38-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,4 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10447-38:
(7*1)+(6*0)+(5*4)+(4*4)+(3*7)+(2*3)+(1*8)=78
78 % 10 = 8
So 10447-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO.ClH/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21;/h1-10,16,19,22H,11-15H2;1H
10447-38-8Relevant articles and documents
Three anhydrous forms and a dihydrate form of quifenadine hydrochloride: A structural study of the thermodynamic stability and dehydration mechanism
Kons, Artis,Rutkovska, Ligita,Berzi??, Agris,Bobrovs, Raitis,Acti??, Andris
, p. 3627 - 3635 (2015/05/20)
Crystal structures of dihydrate (DH) and three anhydrous forms (A, B and C) of quifenadine (1-azabicyclo[2.2.2]oct-8-yl-diphenyl-methanol) hydrochloride are presented, and crystal structure information is used to explain and rationalize the relative stability of polymorphs and observed phase transformations. The dehydration mechanism of the hydrate is provided by interpreting the results obtained in studies of crystal structures, dehydration kinetics and thermal analysis. Structural analysis is used to explain the observed relative stability of the anhydrous phases and the hydrate. The crystal structures have been determined either from single crystal (form DH) or from powder diffraction data (forms A, B and C). All three polymorphs consist of similar hydrogen bonded tetramers, and the structural differences arise due to differences in conformation or/and molecular packing. This journal is
