1044746-87-3Relevant academic research and scientific papers
Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria
Luo, Jia Lin,Jin, Terry,Váradi, Linda,Perry, John D.,Hibbs, David E.,Groundwater, Paul W.
, p. 15 - 26 (2016)
New fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfonamides or 6-hydrazinobenz[de]isoquinoline-1,3-diones with β-alanine. The 6-hydrazinobenz[de]isoquinoline-1,3-diones were also condensed with a range of aryl aldehydes to give the corresponding hydrazones. The photophysical properties of the synthesized amines and hydrazines and their amide, hydrazide and hydrazone derivatives, were examined and they were also incorporated into Columbia agar in order to determine their potential for the detection of pathogenic bacteria.
Quantitative and systematic designing of fluorophores enables ultrasensitive distinguishing carbonyls
Shi, Lei,Yan, Chenxu,Li, Yunyu,Yang, Lixiang,Mao, Wenle,Xia, Wei,Zhang, Lingfan,Chen, Yu,Zhang, Wenqing
, p. 12661 - 12668 (2021/07/25)
Although the use of sophisticated fluorescent probes can improve the detection sensitivity, either the lack of quantitative design for fluorophores or the deficiency of selectivity towards individual species makes it extremely difficult to distinguish homologs accurately. Herein, this study reports a quantitative strategy for the systematic engineering of fluorophoresviadensity functional theory (DFT). A series of seven 1,8-naphthylamide hydrazine (NH-1-7) compounds was elaborately tailored on the basis of the PET mechanism, EPS charge population and the maximum HOMO overlap principle. The results showed that the obtainedNH-4exhibited 300-fold “off-on” signal towards carbonyls with extraordinary reactivity and high solubility. Importantly, the ultra-low limits of detection (LOD) towards multi-carbonyl homologs could reach 1.0 × 10?12M on the ultra-high pressure liquid chromatography (UHPLC) in an 8 min analysis window. This systematic and quantitative engineering of fluorophores lays a bridge between efficient development of novel fluorophores and trace level detection in various matrixes.
Design and synthesis of some 1,8-naphthalimides as fluorescence probes for transition metal ions
Wang, Yingchun,Zhang, Ye,Yi, Xianghui,Qin, Wen
, p. 323 - 326 (2012/08/07)
Some 1,8-naphthalimide derivatives (4a-4d) were designed and synthesized from 1,8-naphthalic anhydride and their structures were characterized by 1H NMR, MS and elementary analysis. Then their fluorescence probes for five transition metal ions Cd2+, Co2+, Cu2+, Ni2+ and Zn2+ was investigated by fluorescence titration, respectively. The results showed that compound 4a can available and selectively probe for cobalt(II) ion, with quenching constant (KSV) 6.37 × 10 3 L mol1 and binding constants (Ka) 3.03 × 10 3 L mol1, respectively.
