1044811-63-3

Upstream product

• 1044811-60-0 ethyl 2-[2-(4-chlorophenyl)-6-iodo-4-oxo-4H-quinazolin-3-yl]-propionate 

Downstream Products

• 1044811-66-6 2-(4-chlorophenyl)-6-iodo-3-[1-(5-mercapto-1,3,4-oxadiazol-2-yl)-ethyl]-3H-quinazolin-4-one 
• 1044811-96-2 1-phenyl-4-{2-[2-(4-chlorophenyl)-6-iodo-4-oxo-4H-(quinazolin-3-yl)ethyl]propionyl}-2-thiosemicarbazide 
• 1044811-81-5 N'-(4-chlorobenzylidene)-2-[2-(4-chlorophenyl)-6-iodo-4-oxo-4H-quinazolin-3-yl]-propionic acid hydrazide 
• 1044811-87-1 N'-formyl-2-[2-(4-chlorophenyl)-6-iodo-4-oxo-4H-quinazolin-3-yl] propionic acid hydrazide 
• 1044811-89-3 N'-ethoxymethylene-2-[2-(4-chlorophenyl)-6-iodo-4-oxo-4H-quinazolin-3-yl] propionic acid hydrazide 
• 1044811-95-1 2-(4-chlorophenyl)-6-iodo-3-[1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives

In this study, we have synthesized a series of 3H-quinazolin-4-ones in order to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of the newly synthesized compounds were confirmed by means of infrared, nuclear magnetic resonance and mass spectroscopy. Some compounds were evaluated for their analgesic and anti-inflammatory activities by writhing and carrageenan-induced rat paw edema tests, respectively. In comparison to the standard drug indomethacine, compounds 4, 6c, 12-14, 16, 18, 19, and 22 induced significant reduction in the writhing response while compounds 6c, 12, 14, 16, 18, and 22 produced a good dose-dependent anti-inflammatory activity. The best dual analgesic/anti-inflammatory relative activity was observed with compounds 6c, 14, 16, 18, and 22.