1044872-73-2

Basic information

• Product Name: C17H28O3Si
• Synonyms: C17H28O3Si;4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylbenzaldehyde;4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3,5-dimethylbenzaldehyde
• CAS NO: 1044872-73-2
• Molecular Formula: C₁₇H₂₈O₃Si
• Molecular Weight: 308.49
• Mol File: 1044872-73-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: C17H28O3Si(CAS DataBase Reference)
• NIST Chemistry Reference: C17H28O3Si(1044872-73-2)
• EPA Substance Registry System: C17H28O3Si(1044872-73-2)

Safety Data

• Hazardous Substances Data: 1044872-73-2(Hazardous Substances Data)

Upstream product

• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 
• 1039948-89-4 4-(2-hydroxy ethoxy)-3,5-dimethyl benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 86864-60-0 2-(tert-butyldimethylsilyloxy)ethyl bromide 
• 134-96-3 syringic aldehyde 

Downstream Products

• 1253732-66-9 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-7-methoxyquinazolin-4(3H)-one 
• 1044871-40-0 6-bromo-2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one 
• 1253732-02-3 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethyl-phenyl}-6-morpholin-4-yl-3H-quinazolin-4-one 
• 1253732-05-6 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-dimethyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 1253732-65-8 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-5-chloroquinazolin-4(3H)-one 
• 1246250-74-7 5,7-difluoro-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-3H-quinazolin-4-one 
• 1253732-44-3 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one 
• 1044870-39-4 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one 
• 1044871-38-6 6-bromo-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one 
• 1044871-11-5 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethylquinazolin-4(3H)-one 
• 1044871-06-8 N-(2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide 
• 1044872-48-1 6-amino-2-(4-(2-hydroxy ethoxy)-3,5-dimethyl phenyl)-3H-quinazolin-4-one 
• 1235480-04-2 3-(4-cyclohexylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one 
• 1235479-99-8 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-3-(4-morpholinophenyl)quinazolin-4(3H)-one 

Relevant articles and documents

Preparation method for Apabetalone

The invention relates to a preparation method for Apabetalone, and particularly discloses a synthesis method for Apabetalone. The preparation method comprises the following steps: (1) a first intermediate, i.e., 2-bromo-4,6-dimethoxy benzamide, is prepared; (2) a second intermediate, i.e., 4-{2-[(t-butyldimethylsilicon)oxy]ethyoxyl}-3,5-dimethyl benzaldehyde, is prepared; (3) the first intermediate and the second intermediate are sealed under the conditions of cuprous bromide, cesium carbonate, L-proline and ammonia hydroxide to react, so that Apabetalone is obtained. The preparation method disclosed by the invention is simple, and yield is high.

NOVEL ANTI-INFLAMMATORY AGENTS

Disclosed are methods of regulating interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1) and methods of treating and/or preventing cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s) by administering a naturally occurring or synthetic quinazolone derivative. The invention provides novel synthetic quinazolone compounds, as well as pharmaceutical compositions comprising those compounds.