104494-92-0Relevant articles and documents
NEPHROTROPIC DRUGS
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, (2008/06/13)
Disclosed are a drug having renal selectivity and a drug carrier for specifically transporting a drug supported thereon to a kidney. A segment structure specifically recognizable in the kidney is utilized. More specifically, since a segment structure repr
Synthesis and antidiuretic activities of novel glycoconjugates of arginine-vasopressin
Susaki, Hiroshi,Suzuki, Kokichi,Ikeda, Masahiro,Yamada, Harutami,Watanabe, Hiroshi K.
, p. 1530 - 1537 (2007/10/03)
Arginine-vasopressin (AVP) was acylated with various acyl azides (2a-j) in pH 9.1 buffer to give AVP derivatives (11a-j) modified at the tyrosine side chain with a carbohydrate via a spacer arm. Glycoconjugates of AVP modified at the N-terminal amide (12a
Syntheses of spacer-armed carbohydrate model compounds
Kerekgyarto, Janos,Nagy, Zoltan,Szurmai, Zoltan
, p. 107 - 115 (2007/10/03)
Commercially available chemicals, such as diethylene glycol, 1,9-nonanediol, 9-decen-1-ol, 1,2,6-hexanetriol, and p-nitrophenol were used to prepare spacer-armed carbohydrate derivatives. Glycosides of D-glucose, N-acetyl-D-glucosamine and 3-O-methyl-D-glucose have been synthesized, carrying reactive groups at the end of the spacer-arms. These glycosides are capable of forming neoglycoproteins. When bromo sugars were reacted with highly apolar aglycones in the presence of mercuric cyanide or mercuric bromide, a considerable amount of '2-OH-compounds' (such as 9-hydroxynonyl 3,4,6-tri-O-acetyl-β-D-glucopyranoside) were formed. Some spacer-armed derivatives (such as 9,10-epoxydecyl β-D-glucopyranoside) are theoretically a mixture of diastereomers, but this fact does not mirror in the 1H and 13C NMR spectra.
Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists
Roy, Rene,Park, William K. C.,Srivastava, Om P.,Foxall, Carrol
, p. 1399 - 1402 (2007/10/03)
Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water- soluble copolyacrylamide showed inhibition of binding of both L- and E- selectins in the μMolar range.