104499-59-4Relevant academic research and scientific papers
2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity
-
, (2008/06/13)
Compounds of formula I, STR1 in which A is a 5 or 6 membered, fully unsaturated, carbocyclic or heterocyclic ring, B is a 5 or 6 membered, fully unsaturated, nitrogen containing heterocyclic ring, X is NR19, O or S, R19 is hydrogen or alkyl optionally substituted by --OCOR, n is 0 or 1, R3, R4, R5, R6, R7, R8, R9 and R10 have various significances, R1 and R2, are hydrogen or alkyl or together with the ring carbon atoms to which they are attached, form a benzene or pyridine ring, which ring carries substituents R15, R16, R17 and R18, R15, R16, R17 and R18, have various significances, with certain provisos are described. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions including excess gastric acid secretion, are also described.
Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
-
, (2008/06/13)
There are described compounds of formula I, STR1 in which A is a benzene or heterocyclic ring, y is 0 or 1, L is a group containing 1 or 2 carbon atoms, or is a single bond, R9 and R10 have a variety of significances, e.g. R10 may form part of a double bond with L, or the group --NR9 R10 forms a ring carrying substituents R1 and R8, or when L is a single bond --NR10 and R8 may form a ring carrying substituents R16 to R25, or the group --LNR9 R10 forms a heterocyclic ring carrying substituents R26 to R33, R1 to R8 and R16 to R33 have a variety of significances n is 0, 1 or 2, x is 3, 4 or 5, X is S, O or NR15, R15 is hydrogen, --COR, --COOR or alkyl optionally substituted by --OCOR, and certain provisos. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions involving excess gastric acid secretion, are also described.
