1045-54-1Relevant academic research and scientific papers
Investigation of the antitumor activity of podocarpic acid derivatives
Parish,Miles
, p. 694 - 696 (1984)
As a class, octahydrophenanthrene lactones, podolactones, and related podocarpic acid derivatives have been reported to possess a wide variety of biological activities, including antileukemic activity, inhibition of plant cell growth, and hormonal and anti-inflammatory properties. In the present study, a series of synthetic intermediates derived from podocarpic acid have been prepared and evaluated with the respect to their ability to inhibit human epidermoid carcinoma of the nasopharynx in vitro. The significant cytotoxicity demonstrated by methyl 6α-bromo-7-oxo-O-methylpodocarpate (50% inhibition at 8.85 x 10-9 M) was markedly higher than that of the other derivatives examined. Further evaluation against L210 and P388 lymphoid leukemias in mice failed to demonstrate significant antitumor activity.
Reactions of η2-tetracarbonylmanganese complexes derived from podocarpic acid with electrophiles; functionalization of ring C
Cambie, Richard C.,Metzler, Michael R.,Rickard, Clifton E. F.,Rutledge, Peter S.,Woodgate, Paul D.
, p. 177 - 198 (2007/10/02)
Reaction of tetracarbonylmanganese(I) complexes derived from podocarpic acid (1) with electrophilic bromine or iodine in CCl4 leads to 14-halogenated derivatives inaccessible by direct halogenation.Similar reactions in protic solvents lead to the formation of γ-lactones in high yield.The structure of one of these was established unequivocally by X-ray crystallograohy.Attempted oxidation of the C-Mn bond with a number of reagents proved generally to be unsuccessful.
