104503-17-5

Upstream product

• 2280-42-4 2-amino-3-hydroxy-valeric acid 
• 501-53-1 benzyl chloroformate 
• 2076-43-9 (+/-)-threo-β-hydroxynorvaline 

Downstream Products

• 105660-59-1 (2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-pentanoic acid; compound with (S)-2-amino-3-(4-hydroxy-phenyl)-propionic acid hydrazide 
• 105660-59-1 (2R,3S)-2-Benzyloxycarbonylamino-3-hydroxy-pentanoic acid; compound with (S)-2-amino-3-(4-hydroxy-phenyl)-propionic acid hydrazide 

Relevant academic research and scientific papers

Oprical resolution of β-Hydroxynorvaline

β-Hydroxy-DL-norvaline (HyNva) was successfully separated into its diastereoisomers by fractional crystallization from 2-propanol as p-toluenesulfonic acid (TsOH) salts.The two racemic diastereoisomers were resolved into four stereoisomers by Vogler's method, using diastereisomers of the N-benzyloxycarbonyl DL-amino acid and L-tyrosine hydrazide.