104553-43-7

Basic information

• Product Name: (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER
• Synonyms: (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER;(S)-Tert-butyl 2-(pyrrolidin-2-yl)acetate;2-Pyrrolidineacetic acid, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 104553-43-7
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.26
• Mol File: 104553-43-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 238.129°C at 760 mmHg
• Flash Point: 97.817°C
• Appearance: /
• Density: 0.966g/cm³
• Vapor Pressure: 0.043mmHg at 25°C
• Refractive Index: 1.448
• Storage Temp.: 2-8°C
• PKA: 10.00±0.10(Predicted)
• CAS DataBase Reference: (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER(104553-43-7)
• EPA Substance Registry System: (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER(104553-43-7)

Safety Data

• Hazardous Substances Data: 104553-43-7(Hazardous Substances Data)

Usage

General Description

(S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C11H21NO2. It is a tertiary butyl ester derivative of the amino acid pyrrolidin-2-yl-acetic acid. (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It is also used as a chiral auxiliary in organic synthesis for the production of enantiomerically pure compounds. Additionally, (S)-PYRROLIDIN-2-YL-ACETIC ACID TERT-BUTYL ESTER has potential applications in the field of medicinal chemistry, particularly in the development of new therapeutic agents.

InChI:InChI=1/C10H19NO2/c1-10(2,3)13-9(12)7-8-5-4-6-11-8/h8,11H,4-7H2,1-3H3/t8-/m0/s1

Upstream product

• 81838-85-9 tert-butyl (2E,4E)-2,4-hexadienoate 
• 164660-17-7 (3R,4E,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-hept-4-enoate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 569679-82-9 (3R,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-pent-4-enoate 
• 468071-45-6 (2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate 
• 16809-92-0 tert-butyl (2E)-penta-2,4-dienoate 
• 852052-53-0 tert-butyl-(E)-6-hydroxyhex-2-enoate 
• 852052-54-1 tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-6-hydroxyhexanoate 
• 852052-44-9 (E)-6-oxo-hex-2-enoic acid tert-butyl ester 
• 852052-45-0 tert-butyl (3S,αS)-3-(N-benzyl-(α-methylbenzyl)amino)-6-oxohexanoate 
• 468071-50-3 (2S,αS)-tert-butyl 1-(N-α-methylbenzylamino)-pyrrolidin-2-yl-acetate 

Downstream Products

• 56633-75-1 (S)-2-(pyrrolidin-2-yl)acetic acid 

Relevant articles and documents

Total synthesis and in vivo evaluation of 8-deoxypumiliotoxin 193H

The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intra

Cyclic β-amino acid derivatives: Synthesis via lithium amide promoted tandem asymmetric conjugate addition-cyclisation reactions

The product distribution upon conjugate addition of homochiral lithium N-benzyl-N-α-methylbenzylamide to dimethyl-(E,E)-nona-2,7-dienedioate can be controlled to give either the cyclic 1,2-anti-1,6-anti-β-amino ester (derived from conjugate addition and i

Ring closing metathesis for the asymmetric synthesis of (S)-homopipecolic acid, (S)-homoproline and (S)-coniine

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to α,β-unsaturated esters or Weinreb amides, followed by ring closing metathesis is used to afford the cyclic β-amino acids (S)-homopipecolic acid and (S)-homoproline and the amine (S)-coniine in high ee.