104560-41-0

Basic information

• Product Name: 1,3-BenzenedicarboxaMide, N,N,N',N'-tetrakis(phenylMethyl)-
• Synonyms: 1,3-BenzenedicarboxaMide, N,N,N',N'-tetrakis(phenylMethyl)-
• CAS NO: 104560-41-0
• Molecular Formula: C₃₆H₃₂N₂O₂
• Molecular Weight: 524.65148
• Mol File: 104560-41-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-BenzenedicarboxaMide, N,N,N',N'-tetrakis(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BenzenedicarboxaMide, N,N,N',N'-tetrakis(phenylMethyl)-(104560-41-0)
• EPA Substance Registry System: 1,3-BenzenedicarboxaMide, N,N,N',N'-tetrakis(phenylMethyl)-(104560-41-0)

Safety Data

• Hazardous Substances Data: 104560-41-0(Hazardous Substances Data)

Upstream product

• 4612-28-6 1,3-phenylenediboronic acid 

Relevant articles and documents

Cu-catalyzed arylation of bromo-difluoro-acetamides by aryl boronic acids, aryl trialkoxysilanes and dimethyl-aryl-sulfonium salts: New entries to aromatic amides

We describe a mechanism-guided discovery of a synthetic methodology that enables the preparation of aromatic amides from 2-bromo-2, 2-difluoroacetamides utilizing a copper-catalyzed direct arylation. Readily available and structurally simple aryl precursors such as aryl boronic acids, aryl trialkoxysilanes and dimethyl-aryl-sulfonium salts were used as the source for the aryl substituents. The scope of the reactions was tested, and the reactions were insensitive to the electronic nature of the aryl groups, as both electron-rich and electron-deficient aryls were successfully introduced. A wide range of 2-bromo-2, 2-difluoroacetamides as either aliphatic or aromatic secondary or tertiary amides were also reactive under the developed conditions. The described synthetic protocols displayed excellent efficiency and were successfully utilized for the expeditious preparation of diverse aromatic amides in good-to-excellent yields. The reactions were scaled up to gram quantities.