104561-32-2

Basic information

• Product Name: Proline, 3-ethyl-, methyl ester (9CI)
• Synonyms: Proline, 3-ethyl-, methyl ester (9CI)
• CAS NO: 104561-32-2
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.2102
• Product Categories: PYRROLE
• Mol File: 104561-32-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Proline, 3-ethyl-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 3-ethyl-, methyl ester (9CI)(104561-32-2)
• EPA Substance Registry System: Proline, 3-ethyl-, methyl ester (9CI)(104561-32-2)

Safety Data

• Hazardous Substances Data: 104561-32-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Inhibitors of farnesyl-protein transferase

The present invention comprises analogs of the CA1 A2 X motif of the protein Ras that is modified by farnesylation in vivo. These CA1 A2 X analogs inhibit the farnesyl-protein transferase and the farnesylation of certain proteins. Furthermore, these CA1 A2 X analogs differ from those previously described as inhibitors of farnesyl-protein transferase in that they do not have a thiol moiety. The lack of the thiol offers unique advantages in terms of improved pharmacokinetic behavior in animals, prevention of thiol-dependent chemical reactions, such as rapid autoxidation and disulfide formation with endogenous thiols, and reduced systemic toxicity. The compounds of the instant invention also incorporate a cyclic amine moiety in the A2 position of the motif. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production.