1045756-12-4

Basic information

• Product Name: 3,5-di-(4'-ethoxybenzyloxy)benzoic acid hydrazide
• Synonyms: 3,5-di-(4'-ethoxybenzyloxy)benzoic acid hydrazide
• CAS NO: 1045756-12-4
• Molecular Weight: 436.508
• Mol File: 1045756-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-di-(4'-ethoxybenzyloxy)benzoic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-di-(4'-ethoxybenzyloxy)benzoic acid hydrazide(1045756-12-4)
• EPA Substance Registry System: 3,5-di-(4'-ethoxybenzyloxy)benzoic acid hydrazide(1045756-12-4)

Safety Data

• Hazardous Substances Data: 1045756-12-4(Hazardous Substances Data)

Upstream product

• 2606-57-7 4-ethoxybenzyl bromide 
• 6214-44-4 4-ethoxybenzyl alcohol 
• 1272974-70-5 3,5-di-(4'-ethoxybenzyloxy)benzoic acid methyl ester 

Downstream Products

• 1045756-05-5 3,5-di-(4'-ethoxybenzyloxy)benzaldehyde 

Relevant articles and documents

Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives

Three series of di- and trisubstituted derivatives of cinnamic alcohol and its conjugated dienol analogues were designed and synthesised. The derivatives were screened for cytotoxicity against nine tumour cell lines: KB, A549, Hela, CNE, PC-3, BEL-7404, HL-60, BGC823 and P388D1. Most of the cinnamic alcohol derivatives showed cytotoxic activity. The compound 7-(4',5'-dichlorobenzyloxy)- 6,8-dihydroxycinnamic alcohol (55) exhibited significant cytotoxicity to seven human tumour cell lines on a micromolar range, especially with regard to the KB and P388D1 cell lines, showing IC50 values of 0.4 and 0.5μ M, respectively. The structure-activity relationships of the derivatives are discussed.