1045822-97-6Relevant articles and documents
Transition-Metal-Free Direct Trifluoromethylthiolation and Trifluoromethylsulfoxidation of Electron-Rich Aromatics with CF3SO2Na in the Presence of PCl3
Zhao, Xia,Wei, Aoqi,Yang, Bo,Li, Tianjiao,Li, Quan,Qiu, Di,Lu, Kui
, p. 9175 - 9181 (2017)
A new transition-metal-free route for the direct trifluoromethylthiolation and trifluoromethylsulfoxidation of electron-rich aromatics with CF3SO2Na in the presence of PCl3 was developed. Notably, PCl3 was used as a reducing and chlorination reagent. The transition-metal-free protocol utilized cheap and readily available reagents and exhibited good atom economy; therefore, it will serve as an alternative and practical strategy for the trifluoromethylthiolation and trifluoromethylsulfoxidation of electron-rich aromatics.
Transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles with sodium trifluoromethanesulfinates in ionic liquids
Wang, Fei,Lu, Guo-Ping,Lin, Yamei
supporting information, (2021/04/12)
An acid-promoted protocol has been developed to achieve the transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles using sodium trifluoromethanesulfinates in an imidazolium-based ionic liquid ([Hmim]Br). [Hmim]Br not only acts as a recyclable solvent, but also as the reductant in this transformation. The advantages of this chemistry include simple operation, use of a recyclable solvent, avoidance of transition-metal and phosphorus, and gram-scale synthesis.
Method for synthesizing trifluoromethyl sulfidethioetherified indole derivatives
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Paragraph 0075-0079, (2018/12/13)
The invention discloses a method for synthesizing trifluoromethyl sulfidethioetherified indole derivatives. The method comprises the steps of: performing reaction of sodium trifluoromethylsulfinate with indole derivatives in a solvent in which phosphorus trichloride is uniformly distributed with phosphorus trichloride, wherein the reaction temperature is 60 DEG C and the reaction time is 0.33-10 hours. The mole ratio of sodium trifluoromethylsulfinate to the indole derivatives to phosphorus trichloride is (7.5-5):5:(7.5-5). The raw materials for the synthesis method provided by the invention is cheap and easy to be obtained. The trifluoromethyl sulfidethioetherification reagent used is sodium trifluoromethylsulfinate which is stable in chemical properties, cheap and easy to be obtained.
Transition-metal-free direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2
Zhao, Xia,Zheng, Xiancai,Tian, Miaomiao,Sheng, Jianqiao,Tong, Yifan,Lu, Kui
, p. 7233 - 7238 (2017/11/27)
A novel transition metal-free route for the direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2 was developed. More specifically, PhPCl2 was used as both a reducing and a chlorinating reagent for the first time in this CF3SO2Na-based trifluoromethylthiolation reaction. The absence of transition metals and the use of cheap and readily available reagents render this method an alternative and practical strategy for the trifluoromethylthiolation of electron-rich aromatics.
